Clinical approach to Parkinson's disease: features, diagnosis, and principles of management
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
condition causes a heavy burden both on those affected, as well as their families. Accurate …
condition causes a heavy burden both on those affected, as well as their families. Accurate …
Circadian disruption and sleep disorders in neurodegeneration
Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics
Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes
characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in …
characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in …
Priorities in Parkinson's disease research
WG Meissner, M Frasier, T Gasser, CG Goetz… - Nature reviews Drug …, 2011 - nature.com
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
N Ferreira, H Gram, ZA Sorrentino, E Gregersen… - Acta …, 2021 - Springer
Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …
the nervous system in a variety of neurodegenerative disorders including Parkinson's …
The neuropathology, pathophysiology and genetics of multiple system atrophy
Z Ahmed, YT Asi, A Sailer, AJ Lees… - Neuropathology and …, 2012 - Wiley Online Library
Z. Ahmed, YT Asi, A. Sailer, AJ Lees, H. Houlden, T. Revesz and JL Holton (2012)
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …
Are synucleinopathies prion-like disorders?
E Angot, JA Steiner, C Hansen, JY Li… - The Lancet …, 2010 - thelancet.com
A shared neuropathological feature of idiopathic Parkinson's disease, dementia with Lewy
bodies, and multiple system atrophy is the development of intracellular aggregates of α …
bodies, and multiple system atrophy is the development of intracellular aggregates of α …
[HTML][HTML] Medical management and prevention of motor complications in Parkinson's disease
Levodopa is the most effective medication for the treatment of the motor symptoms of
Parkinson's disease. However, over time, the clinical response to levodopa becomes …
Parkinson's disease. However, over time, the clinical response to levodopa becomes …
[HTML][HTML] Glia and alpha-synuclein in neurodegeneration: A complex interaction
Abstract α-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative
disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple …
disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple …
Diagnostic approach to atypical parkinsonian syndromes
NR McFarland - CONTINUUM: Lifelong Learning in Neurology, 2016 - journals.lww.com
Abstract Purpose of Review: Although increasingly recognized, atypical parkinsonian
syndromes remain challenging to diagnose and are underrecognized due to overlap with …
syndromes remain challenging to diagnose and are underrecognized due to overlap with …