Overexpression of the human epidermal growth factor-2 (HER2) oncogene in human breast
carcinomas has been associated with a more aggressive course of disease. The reason for …

Integrins are a large family of heterodimeric transmembrane receptors that mediate cell-
substratum adhesion. αvβ6 is an epithelial-specific integrin that is a receptor for the …

In contrast to the epidermal growth factor (EGF) receptor, ErbB2 is known to remain at the
plasma membrane after ligand binding and dimerization. However, why ErbB2 is not …

ErbB2, a metastasis-promoting oncoprotein, is overexpressed in∼ 25% of
invasive/metastatic breast cancers, but in 50%–60% of noninvasive ductal carcinomas in …

Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and
inhibition of developmental and postischemic angiogenesis. Sema3E is also highly …

Aims and background The PI3 kinase signalling pathway is now accepted as being at least
as important as the ras-MAP kinase pathway in cell survival and proliferation, and hence its …

Border cell migration in the Drosophila ovary is a relatively simple and genetically tractable
model for studying the conversion of epithelial cells to migratory cells. Like many cell …

The formation of HER2 homodimers plays an important role in breast cancer
aggressiveness and progression; however, little is known about its localization. We have …

HER2 (human epidermal growth factor receptor-2; also known as erbB2) and its relatives
HER1 (epidermal growth factor receptor; EGFR), HER3 and HER4 belong to the HER family …

MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually
all breast cancers. MUC1 is normally restricted to the apical surface of epithelia and loss of …