▪ Abstract As the basic unit of life, the cell is a biologically complex system, the
understanding of which requires a combination of various approaches including …

Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

Monoclonal antibodies are used in numerous therapeutic and diagnostic applications;
however, their efficacy is contingent on specificity and avidity. Here, we show that …

The specific adhesive interaction between a non-spherical particle and a cell layer under a
linear shear flow is analyzed. The effect of the characteristic particle size, expressed in terms …

To what extent the growth dynamics of tumors is controlled by nutrients, biomechanical
forces and other factors at different stages and in different environments is still largely …

We report a novel method for measuring forward and reverse kinetic rate constants, k fo and
kr 0, for the binding of individual receptors and ligands anchored to apposing surfaces in cell …

In this paper we compare two alternative theoretical approaches for simulating the growth of
cell aggregates in vitro: individual cell (agent)-based models and continuum models. We …

We present a three-dimensional individual cell-based, biophysical model to study the effect
of normal and malfunctioning growth regulation and control on the spatial-temporal …

The formation and dissociation of specific noncovalent interactions between a variety of
macromolecules play a crucial role in the function of biological systems. During the last few …

Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased
tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their …