Interest in cancer metabolism has increased in recent years. The pentose phosphate
pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its …

Highlights•Chloroquine is used for anti-malaria, anti-cancer and anti-virus treatment.•The
efficacy of hydroxychloroquine against COVID-19 is controversial.•Several quinoline …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Radiation is a critical pillar in cancer therapeutics, exerting its anti-tumor DNA-damaging
effects through various direct and indirect mechanisms. Radiation has served as an effective …

Background Lysosome-associated agents have been implicated as possible chemo-
sensitizers and immune regulators for cancer chemotherapy. We investigated the potential …

It has long been debated whether a little stress may be “good” for you. Extensive evidence
has now sufficiently accumulated demonstrating that low doses of a vast range of chemical …

Many lysosome functions are determined by a lumenal pH of∼ 5.0, including the activity of
resident acid-activated hydrolases. Lysosome pH (pHlys) is often increased in …

Background: The concentration and duration of intracellular drugs have always been the key
factors for determining the efficacy of the treatment. Efflux of chemotherapeutic drugs or …

Pharmacological inhibition of ribosome biogenesis is a promising avenue for cancer
therapy. Herein, we report a novel activity of the FDA-approved antimalarial drug …

Opinion statement The primordial autophagy process, originally identified as a starvation
response in baker's yeast, has since been shown to have a wide spectrum of functions other …