Cognitive impairment in psychotic illness: prevalence, profile of impairment, developmental course, and treatment considerations

A McCleery, KH Nuechterlein - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Despite effective pharmacological treatments for psychotic symptoms (eg, hallucinations,
delusions), functional outcomes for people with psychotic disorders are often disappointing …

Neurocognitive deficit in schizophrenia: a quantitative review of the evidence.

RW Heinrichs, KK Zakzanis - Neuropsychology, 1998 - psycnet.apa.org
The neurocognitive literature on test performance in schizophrenia is reviewed
quantitatively. The authors report 22 mean effect sizes from 204 studies to index …

Schizophrenia is a cognitive illness: time for a change in focus

RS Kahn, RSE Keefe - JAMA psychiatry, 2013 - jamanetwork.com
Schizophrenia is currently classified as a psychotic disorder. This article posits that this
emphasis on psychosis is a conceptual fallacy that has greatly contributed to the lack of …

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

MF Egan, TE Goldberg, BS Kolachana… - Proceedings of the …, 2001 - National Acad Sciences
Abnormalities of prefrontal cortical function are prominent features of schizophrenia and
have been associated with genetic risk, suggesting that susceptibility genes for …

Memory impairment in schizophrenia: a meta-analysis

A Aleman, R Hijman, EHF De Haan… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: Memory impairment is well documented in schizophrenia. Less is known,
however, about the exact magnitude, pattern, and extent of the impairment. The effect of …

Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia

AJ Saykin, DL Shtasel, RE Gur, DB Kester… - Archives of general …, 1994 - jamanetwork.com
Background: Medication and chronicity have complicated past attempts to characterize the
neuropsychological performance of patients with schizophrenia. There have been …

Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria

MF Green, KH Nuechterlein, JM Gold, DM Barch… - Biological …, 2004 - Elsevier
To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the
National Institute of Mental Health (NIMH) established the Measurement and Treatment …

Cognitive impairment in schizophrenia

RSE Keefe, PD Harvey - Novel antischizophrenia treatments, 2012 - Springer
Cognitive functioning is moderately to severely impaired in patients with schizophrenia. This
impairment is the prime driver of the significant disabilities in occupational, social, and …

Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia

JM Gold, C Carpenter, C Randolph… - Archives of general …, 1997 - jamanetwork.com
Background: Impaired Wisconsin Card Sorting Test (WCST) performance has been one
critical piece of evidence suggesting frontal lobe dysfunction in schizophrenia. However, the …

Is it possible to be schizophrenic yet neuropsychologically normal?

BW Palmer, RK Heaton, JS Paulsen, J Kuck… - …, 1997 - psycnet.apa.org
This study identified and characterized a group of schizophrenic patients without
neuropsychological (NP) impairment. A comprehensive NP battery was administered to 171 …