Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

Because of their pervasiveness in eukaryotic genomes and their unique properties,
understanding the role that ID (intrinsically disordered) regions in proteins play in the …

Interactome maps are valuable resources to elucidate protein function and disease
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …

Hubs are proteins with a large number of interactions in a protein-protein interaction
network. They are the principal agents in the interaction network and affect its function and …

Proteins, these evolutionarily-edited biological polymers, are able to undergo intramolecular
and intermolecular phase transitions. Spontaneous intramolecular phase transitions define …

Circulating extracellular vesicles (EVs) are membrane-bound nanoparticles secreted by
most cells for intracellular communication and transportation of biomolecules. EVs carry …

It is now increasingly evident that a large fraction of the human proteome comprises proteins
that, under physiological conditions, lack fixed, ordered 3D structures as a whole or have …

Biologically active proteins without stable tertiary structure are common in all known
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …

Oxidative genome damage induced by reactive oxygen species includes oxidized bases,
abasic (AP) sites, and single-strand breaks, all of which are repaired via the evolutionarily …

Protein evolution is not simply a race toward improved function. Because organisms
compete for limited resources, fitness is also affected by the relative economy of an …