The roles of the amyloid beta monomers in physiological and pathological conditions
Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the
amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of …
amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of …
The regulatory role of Pin1 in neuronal death
SC Wang, XM Hu, K Xiong - Neural Regeneration Research, 2023 - journals.lww.com
Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis.
It is vital that we understand how key regulatory signals can control the process of cell death …
It is vital that we understand how key regulatory signals can control the process of cell death …
Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response
NR Stallings, MA O'Neal, J Hu, ZJ Shen… - Alzheimer's Research & …, 2023 - Springer
Abstract Background Current treatments for Alzheimer's disease (AD) have largely failed to
yield significant therapeutic benefits. Novel approaches are desperately needed to help …
yield significant therapeutic benefits. Novel approaches are desperately needed to help …
Exploring the association between cancer and cognitive impairment in the Australian Imaging Biomarkers and Lifestyle (AIBL) study
An inverse association between cancer and Alzheimer's disease (AD) has been
demonstrated; however, the association between cancer and mild cognitive impairment …
demonstrated; however, the association between cancer and mild cognitive impairment …
Application of codon usage and context analysis in genes up-or down-regulated in neurodegeneration and cancer to combat comorbidities
Introduction Neurodegeneration and cancer present in comorbidities with inverse effects
due to the expression of genes and pathways acting in opposition. Identifying and studying …
due to the expression of genes and pathways acting in opposition. Identifying and studying …
The spectrum of Alzheimer-type pathology in cognitively normal individuals
JM Walker, SK Dehkordi, J Schaffert… - Journal of …, 2023 - content.iospress.com
Background: The strongest risk factor for the development of Alzheimer's disease (AD) is
age. The progression of Braak stage and Thal phase with age has been demonstrated …
age. The progression of Braak stage and Thal phase with age has been demonstrated …
Alzheimer's Disease: Exploring the Landscape of Cognitive Decline
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …
Marginalizing the genomic architecture to identify crosstalk across cancer and neurodegeneration
Cancer and neurodegenerative diseases (NDD) appear mechanistically distinct, ie, the
former acquires mechanisms to resist and evade cell death, while the latter is characterized …
former acquires mechanisms to resist and evade cell death, while the latter is characterized …
Oligomer‐Aβ42 suppress glioma progression via potentiating phagocytosis of microglia
J Lu, Z Wang, Z He, Y Hu, H Duan, Z Liu… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Glioma is characterized by an immunosuppressed environment and a poor prognosis.
The accumulation of Amyloid β (A β) leads to an active environment during the early stages …
The accumulation of Amyloid β (A β) leads to an active environment during the early stages …
Alzheimer's Disease and Different Types of Cancer Likelihood: Unveiling Disparities and Potential Protective Effects in a Korean Cohort Study
Simple Summary This study investigates the potential link between Alzheimer's disease
(AD) and the probability of developing various cancers using a large cohort dataset in Korea …
(AD) and the probability of developing various cancers using a large cohort dataset in Korea …