Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Brazil currently contributes 42% of all malaria cases reported in the Latin America and the
Caribbean, a region where major progress towards malaria elimination has been achieved …

Malaria is the tropical disease most commonly imported into the UK, with 1300–1800 cases
reported each year, and 2–11 deaths. 2. Approximately three quarters of reported malaria …

Most malaria drug development focuses on parasite stages detected in red blood cells, even
though, to achieve eradication, next-generation drugs active against both erythrocytic and …

Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …

Abstract Glucose-6-phosphate dehydrogenase (G6PD) is a potentially pathogenic inherited
enzyme abnormality and, similar to other human red blood cell polymorphisms, is …

Microneedle (MN) patches consist of a hydrogel‐forming MN array and a drug‐containing
reservoir. Drug‐containing reservoirs documented in the literature include polymeric films …

Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic
(liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly …

The gravity of the threat posed by vivax malaria to public health has been poorly
appreciated. The widely held misperception of Plasmodium vivax as being relatively …