Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

African swine fever virus (ASFV), a nucleocytoplasmic large DNA virus (NCLDV), causes
African swine fever (ASF), an acute hemorrhagic disease with mortality rates up to 100% in …

Nature uses multivalency to govern many biological processes. The development of
macromolecular and cellular therapies has largely been dependent on engineering similar …

ABSTRACT A large body of data exists demonstrating that neonatal Fc receptor (FcRn)
binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG …

The adaptive immune system is tasked with producing antibodies that recognize a wide
scope of potential pathogens, including those never before encountered, and concurrently …

Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier
(BBB), which is formed by the brain capillary endothelium. Biologics can be re-engineered …

We develop and analyze mathematical models for receptor-mediated transcytosis of
monoclonal antibodies (MAb) targeting the transferrin receptor (TfR) or the insulin receptor …

Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's
disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well …

Photoimmunotherapy (PIT) combines the specificity of antibodies with the cytotoxicity of light
activatable photosensitizers (PS) and is a promising new cancer therapy. We designed and …