Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a
polyphenol natural product isolated from the rhizome of the plant Curcuma longa. For …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Identifying essential genes in a given organism is important for research on their
fundamental roles in organism survival. Furthermore, if possible, uncovering the links …

Abstract Superoxide dismutase 1 (Sod1) has been known for nearly half a century for
catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in …

Background Clear-cell renal-cell carcinomas display divergent clinical behaviours.
However, the molecular genetic events driving these behaviours are unknown. We …

Ribosome biogenesis is a complex and energy-demanding process requiring tight
coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the …

Cell-size homeostasis entails a fundamental balance between growth and division. The
budding yeast Saccharomyces cerevisiae establishes this balance by enforcing growth to a …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …

It is not known how the volume of the cell nucleus is set, nor how the ratio of nuclear volume
to cell volume (N/C) is determined. Here, we have measured the size of the nucleus in …