Distinct molecular signatures of quiescent and activated adult neural stem cells reveal specific interactions with their microenvironment

L Morizur, A Chicheportiche, LR Gauthier, M Daynac… - Stem cell reports, 2018 - cell.com
Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs)
is crucial for the development of therapeutic strategies based on the stimulation of their …

Sox2 Controls Neural Stem Cell Self-Renewal Through a Fos-Centered Gene Regulatory Network

M Pagin, M Pernebrink, S Giubbolini, C Barone… - Stem Cells, 2021 - academic.oup.com
The Sox2 transcription factor is necessary for the long-term self-renewal of neural stem cells
(NSCs). Its mechanism of action is still poorly defined. To identify molecules regulated by …

Metabolic regulation and glucose sensitivity of cortical radial glial cells

BG Rash, N Micali, AJ Huttner… - Proceedings of the …, 2018 - National Acad Sciences
The primary stem cells of the cerebral cortex are the radial glial cells (RGCs), and
disturbances in their operation lead to myriad brain disorders in all mammals from mice to …

Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates

N Micali, SK Kim, M Diaz-Bustamante, G Stein-O'Brien… - Cell reports, 2020 - cell.com
Better understanding of the progression of neural stem cells (NSCs) in the developing
cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of …

Cyclin-dependent kinase 4 regulates adult neural stem cell proliferation and differentiation in response to insulin

L Chirivella, M Kirstein, SR Ferrón… - Stem Cells, 2017 - academic.oup.com
Insulin is one of the standard components used to culture primary neurospheres. Although it
stimulates growth of different types of cells, the effects of insulin on adult neural stem cells …

Role of endogenous basic fibroblast growth factor in stem cells isolated from human exfoliated deciduous teeth

N Nowwarote, P Pavasant, T Osathanon - Archives of Oral Biology, 2015 - Elsevier
Objective This study aimed to investigate the role of endogenous basic fibroblast growth
factor (bFGF) in stem cells isolated from human exfoliated deciduous teeth. Methods Cells …

Fibroblast growth factor 2 enhances BMSC stemness through ITGA2‐dependent PI3K/AKT pathway activation

N Jiang, Z Hu, Q Wang, J Hao, R Yang… - Journal of Cellular …, 2024 - Wiley Online Library
Bone marrow‐derived mesenchymal stem cells (BMSC) are promising cellular reservoirs for
treating degenerative diseases, tissue injuries, and immune system disorders. However, the …

Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after …

R Wang, DX Yang, YL Liu, J Ding, Y Guo… - Neural Regeneration …, 2022 - journals.lww.com
Our previous study showed that cell cycle exit and neuronal differentiation 1 (CEND1) may
participate in neural stem cell cycle exit and oriented differentiation. However, whether …

Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells

T Takehara, T Teramura, Y Onodera, J Frampton… - Scientific reports, 2015 - nature.com
The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell
adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem …

ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon

W Shi, X Chen, F Wang, M Gao, Y Yang… - Developmental …, 2016 - Wiley Online Library
In vertebrates, neural stem/progenitor cells (NSPCs) maintenance is critical for nervous
system development and homeostasis. However, the molecular mechanisms underlying the …