Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …

In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Background Disabling pansclerotic morphea (DPM) is a rare systemic inflammatory
disorder, characterized by poor wound healing, fibrosis, cytopenias …

The subcommittee reviewed the prevalence, incidence, risk factors, natural history, morbidity
and questionnaires reported in epidemiological studies of dry eye disease (DED). A meta …

Key Clinical Points Primary Sjögren's Syndrome A diagnosis of primary Sjögren's syndrome
is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine
glands (mainly the salivary and lacrimal glands) and results in the severe dryness of …

There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …