The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Neuroinflammation plays a critical role in the progression of many neurodegenerative,
neuropsychiatric and viral diseases. In neuroinflammation, activated microglia and …

Dendritic spines are the postsynaptic receptive regions of most excitatory synapses, and
their morphological plasticity play a pivotal role in higher brain functions, such as learning …

Emerging evidence indicates that once established, synapses and dendrites can be
maintained for long periods, if not for the organism's entire lifetime. In contrast to the wealth …

Dendritic spines are actin-rich compartments that protrude from the microtubule-rich
dendritic shafts of principal neurons. Spines contain receptors and postsynaptic machinery …

Glutamatergic synapses in the central nervous system are characterized by an electron-
dense web underneath the postsynaptic membrane; this web is called the postsynaptic …

Interactions between dynamic microtubules and actin filaments (F-actin) underlie a range of
cellular processes including cell polarity and motility. In growth cones, dynamic microtubules …

Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …

Age-related cognitive decline occurs without frank neurodegeneration and is the most
common cause of memory impairment in aging individuals. With increasing longevity …

During development, dynamic changes in the axonal growth cone and dendrite are
necessary for exploratory movements underlying initial axo‐dendritic contact and ultimately …