Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …

Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones,
which participate in protein folding and maturation in response to stresses or high …

The heat shock response (HSR) is a highly conserved cellular pathway that is responsible
for stress relief and the refolding of denatured proteins [1]. When a host cell is exposed to …

Gram-positive bacteria, including Staphylococcus aureus are endemic in the US, which
cause life-threatening necrotizing pneumonia. Neutrophils are known to be critical for …

Establishing the balance between positive and negative innate immune mechanisms is
crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two …

Small cell lung cancer (SCLC) remains one of the most lethal malignancies and a major
health riddle. The therapeutic options are limited. The combination of etoposide or irinotecan …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

The respiratory system exposed to microorganisms continuously, and the pathogenicity of
these microbes not only contingent on their virulence factors, but also the host's immunity. A …

Abstract The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play
important protective roles in host immune response to a variety of infections such as …