The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

The insulin-like growth factor 1 (IGF1) signaling pathway is implicated in the development of
cancer. High levels of circulating IGF1 and certain genetic polymorphisms of IGF1 and …

The close relationship between the biological behaviour of malignant cells and the local
microenvironment where they reside is a feature of diverse neoplasias. Multiple myeloma …

Survivin is a dual regulator of cell proliferation and cell viability overexpressed in most
human tumors. Although strategies to lower survivin levels have been pursued for rational …

There is abundant in vitro, animal and epidemiologic evidence to suggest that the Insulin-
Like Growth Factor (IGF) family is a multi-component network of molecules which is involved …

The type I insulin-like growth factor receptor (IGF1R) and insulin receptor (IR) are structurally
and functionally related heterotetrameric receptors. Activation of IGF1R has been shown to …

The insulin and insulin-like growth factor (IGF) system plays an important role in regulating
normal cell proliferation and survival. However, the IGF system is also implicated in many …

The insulin-like growth factor 1 receptor (IGF-1R) and its associated signalling system has
provoked considerable interest over recent years as a novel therapeutic target in cancer. A …

Many types of adult stem cells exist in a state of cell-cycle quiescence, yet it has remained
unclear whether quiescence plays a role in maintaining the stem cell fate. Here we establish …