Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …

Tobacco smoking has been established to contribute to the pathogenesis of various
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …

One major challenge associated with lung cancer organoids (LCOs) is their predominant
derivation from surgical specimens of patients with early-stage lung cancer. However …

The global burden of pulmonary disease highlights an overwhelming need in improving our
understanding of lung development, disease, and treatment. It also calls for further advances …

Bovine respiratory disease (BRD) is a multifactorial condition where different genera of
bacteria, such as Mannheimia haemolytica, Histophilus somni, Pasteurella multocida, and …

Infections caused by the Gram-negative pathogen Pseudomonas aeruginosa are emerging
worldwide as a major threat to human health. Conventional antibiotic monotherapy suffers …

Lung tissue has a certain regenerative ability and triggers repair procedures after injury.
Under controllable conditions, lung tissue can restore normal structure and function …

Firefighters are the principal line of defense against fires, being at elevated risk of exposure
to health-relevant pollutants released during fires and burning processes. Although many …

Organoids can be derived from various cell types in the lung, and they provide a
reproducible and tractable model for understanding the complex signals driving cell fate …

Being a vital organ exposed to the external environment, the lung is susceptible to a
plethora of pathogens and pollutants. This is reflected in high incidences of chronic …