Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

Global prevalence of obesity in patients with psoriasis: An analysis in the past two decades

J Wang, Y Yu, L Liu, C Wang, X Sun, Y Zhou… - Autoimmunity …, 2024 - Elsevier
Background Psoriasis and obesity are risk factors for psoriasis. Therefore, we conducted a
comprehensive review and meta-analysis to determine the prevalence of obesity in patients …

Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms

S Zhang, J Wang, L Liu, X Sun, Y Zhou… - Frontiers in …, 2022 - frontiersin.org
Background: Psoriasis is a chronic and immune-mediated inflammatory skin disease. Many
studies have shown that curcumin (CUR) has strong anti-inflammatory effects and can …

A review of the clinical trial landscape in psoriasis: an update for clinicians

A Drakos, R Vender - Dermatology and Therapy, 2022 - Springer
As our understanding of the pathogenesis of psoriasis has evolved over the past two
decades, so has the number of treatment options. The introduction of biologic agents …

[HTML][HTML] Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte

R Jiang, J Xu, Y Zhang, J Liu, Y Wang, M Chen… - Biomedicine & …, 2022 - Elsevier
Abstract Ligusticum chuanxiong Hort (Ligusticum; Apiaceae)(accepted name, Ligusticum
striatum DC, on “The Plant List” for the latest version) is a Chinese herbal medicine (CHM) …

Emerging Oral Therapies for the Treatment of Psoriasis: A Review of Pipeline Agents

A Drakos, T Torres, R Vender - Pharmaceutics, 2024 - mdpi.com
The introduction of biologic agents for the treatment of psoriasis has revolutionized the
current treatment landscape, targeting cytokines in the interleukin (IL)-23/IL-17 pathway and …

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

K Masuda-Kuroki, S Alimohammadi, A Di Nardo - Cells, 2023 - mdpi.com
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on
the skin's surface. It involves various skin cells, including keratinocytes, dendritic cells, T …

Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice

Z Weng, H Fu, Z Huang, W Li, Y Xie, J Yuan… - Chemico-Biological …, 2023 - Elsevier
Psoriasis is one kind of autoimmune skin disease without efficiency cure. Shikonin (SHK) is
a potential drug for psoriasis treatment. Recent study suggested that ferroptosis involved in …

[HTML][HTML] The Impact of Statins on Disease Severity and Quality of Life in Patients with Psoriasis: A Systematic Review and Meta-Analysis

AM Aleid, G Almutairi, R Alrizqi, HY Nukaly… - Healthcare, 2024 - mdpi.com
Background: Psoriasis, a chronic autoimmune condition, imposes significant burdens on
patients' well-being. While corticosteroid medications are commonly used, their prolonged …

New and emerging oral therapies for psoriasis

O Yilmaz, JP Pinto, T Torres - Drugs in Context, 2024 - pmc.ncbi.nlm.nih.gov
Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the global population.
Traditional systemic treatments, such as methotrexate, cyclosporine, acitretin and fumaric …