Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Although several dozen studies of gene expression in sepsis have been published,
distinguishing sepsis from a sterile systemic inflammatory response syndrome (SIRS) is still …

Putting the Patient Back Together â•fl Social Medicine, Network Medicine, and the Limits of
Reductionism Page 1 Medicine and Society The new england journal of medicine n engl j …

Chronic obstructive pulmonary disease (COPD) is a complex disease at the clinical, cellular,
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …

Introduction Sepsis is thought to be an abnormal inflammatory response to infection.
However, most clinical trials of drugs that modulate the inflammatory response of sepsis …

Sepsis is a complex inflammatory response to infection. Microarray-based gene expression
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …

There is currently no reliable tool available to measure immune dysfunction in septic
patients in the clinical setting. This proof-of-concept study assesses the potential of gene …

Antimicrobial stewardship involves a multifaceted approach that strives to combat the
emergence of resistance, improve clinical outcomes, and control costs by improving …