Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

Alternate DNA structures that deviate from B‐form double‐stranded DNA such as G‐
quadruplex (G4) DNA can be formed by sequences that are widely distributed throughout …

In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and
mitochondrial genomes, but its role in these processes is still poorly understood. Here, we …

Helicases are ubiquitous enzymes found in all organisms that are necessary for all (or
virtually all) aspects of nucleic acid metabolism. The Pif1 helicase family is a group of 5′→ …

In human mitochondria the transcription machinery generates the RNA primers needed for
initiation of DNA replication. A critical feature of the leading-strand origin of mitochondrial …

Pif1p is the prototypical member of the PIF1 family of DNA helicases, a subfamily of SFI
helicases conserved from yeast to humans. Baker's yeast Pif1p is involved in the …

The acquisition of mutations is relevant to every aspect of genetics, including cancer and
evolution of species on Darwinian selection. Genome variations arise from rare stochastic …

During replication, folding of the DNA template into non-B-form secondary structures
provides one of the most abundant impediments to the smooth progression of the replisome …

The proper functioning of the cell depends on preserving the cellular genome. In yeast cells,
a limited number of genes are located on mitochondrial DNA. Although the mechanisms …

Mitochondrial DNA (mtDNA) is organized in nucleoprotein particles called nucleoids. Each
nucleoid, which is considered a heritable unit of mtDNA, might contain several copies of the …