E‐cadherin (E‐cad) plays important roles in tumorigenesis as well as in tumor progression,
invasion and metastasis. This protein exists in two forms: a membrane‐tethered form and a …

The limitations of current anti-angiogenic therapies necessitate other targets with
complimentary mechanisms. Here, we show for the first time that soluble E-cadherin (sE …

Breast cancer, one of the leading causes of mortality and morbidity among females, is
regulated in part by diverse classes of adhesion molecules one of which is known as …

Background & Aims Pancreatic ductal adenocarcinomas (PDACs) are characterized by
fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated …

Epithelial remodeling involves ratcheting behavior whereby periodic contractility produces
transient changes in cell-cell contact lengths, which stabilize to produce lasting …

Breast cancer growth can be studied in mice using a plethora of models. Genetic
manipulation of breast cancer cells may provide insights into the functions of proteins …

Cellular senescence acts as a potent tumor-suppression mechanism in mammals; however,
it also promotes tumor progression in a non-cell-autonomous manner. We provided insights …

The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a
soluble form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E …

One of the most promising strategies to treat cancer is the use of therapeutic antibodies that
disrupt cell–cell adhesion mediated by dysregulated cadherins. The principal site where cell …

In epithelial cancers, carcinoma cells coexist with normal cells. Although it is known that the
tumor microenvironment (TME) plays a pivotal role in cancer progression, it is not completely …