Platelet and megakaryocyte roles in innate and adaptive immunity
M Koupenova, AC Livada, CN Morrell - Circulation research, 2022 - Am Heart Assoc
Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …
hemostasis and thrombosis. This important platelet function has received significant …
Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria
AP Kaplan, AM Giménez‐Arnau, SS Saini - Allergy, 2017 - Wiley Online Library
The monoclonal anti‐immunoglobulin E (IgE) antibody, omalizumab, was the first drug
approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who …
approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who …
Classification, diagnosis, and approach to treatment for angioedema: consensus report from the H ereditary A ngioedema I nternational W orking G roup
Angioedema is defined as localized and self‐limiting edema of the subcutaneous and
submucosal tissue, due to a temporary increase in vascular permeability caused by the …
submucosal tissue, due to a temporary increase in vascular permeability caused by the …
In vivo roles of factor XII
T Renné, AH Schmaier, KF Nickel… - Blood, The Journal …, 2012 - ashpublications.org
Abstract Coagulation factor XII (FXII, Hageman factor, EC= 3.4. 21.38) is the zymogen of the
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …
Plasma bradykinin in angio-oedema
Background Bradykinin is believed to be the main mediator of symptoms in hereditary (HA)
and acquired (AA) angio-oedema due to C1 esterase inhibitor deficiency, as well as in angio …
and acquired (AA) angio-oedema due to C1 esterase inhibitor deficiency, as well as in angio …
[HTML][HTML] Hereditary angio-oedema
H Longhurst, M Cicardi - The Lancet, 2012 - thelancet.com
Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This
inhibitor regulates several inflammatory pathways, and patients with hereditary angio …
inhibitor regulates several inflammatory pathways, and patients with hereditary angio …
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
A Agostoni, E Aygören-Pürsün, KE Binkley… - Journal of Allergy and …, 2004 - Elsevier
Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …
Hereditary angioedema: a broad review for clinicians
UC Nzeako, E Frigas, WJ Tremaine - Archives of Internal …, 2001 - jamanetwork.com
Hereditary angioedema (HAE) is an autosomal dominant disease that afflicts 1 in 10 000 to
1 in 150 000 persons; HAE has been reported in all races, and no sex predominance has …
1 in 150 000 persons; HAE has been reported in all races, and no sex predominance has …
Biological activities of C1 inhibitor
AE Davis III, P Mejia, F Lu - Molecular immunology, 2008 - Elsevier
Broadly speaking, C1 inhibitor plays important roles in the regulation of vascular
permeability and in the suppression of inflammation. Vascular permeability control is exerted …
permeability and in the suppression of inflammation. Vascular permeability control is exerted …
C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress
C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of
genetic or acquired conditions, and this causes an episodic, local increase in vascular …
genetic or acquired conditions, and this causes an episodic, local increase in vascular …