A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

The new biology and pharmacology of glucagon

TD Müller, B Finan, C Clemmensen… - Physiological …, 2017 - journals.physiology.org
In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

P Westermark, A Andersson… - Physiological …, 2011 - journals.physiology.org
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Type 2 diabetes as a protein misfolding disease

A Mukherjee, D Morales-Scheihing, PC Butler… - Trends in molecular …, 2015 - cell.com
Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …

Amylin: pharmacology, physiology, and clinical potential

DL Hay, S Chen, TA Lutz, DG Parkes, JD Roth - Pharmacological reviews, 2015 - ASPET
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

P Westermark, U Engström… - Proceedings of the …, 1990 - National Acad Sciences
Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic
beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 …

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

A Lorenzo, B Razzaboni, GC Weir, BA Yankner - Nature, 1994 - nature.com
THE 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits
that form in the islets of Langerhans in patients with type-2 diabetes mellitus1–5, but its role …

Islet amyloid polypeptide: structure, function, and pathophysiology

R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

Vascular actions of calcitonin gene-related peptide and adrenomedullin

SD Brain, AD Grant - Physiological reviews, 2004 - journals.physiology.org
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Q Cao, DR Boyer, MR Sawaya, P Ge… - Nature structural & …, 2020 - nature.com
Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone but
deposits as amyloid fibrils in more than 90% of patients with type II diabetes (T2D). Here we …