ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and transmission control measures led to a decrease in the global malaria burden over the …
The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′- cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most …
RJ Cardenas, L Chacín-Bonilla… - Melatonin …, 2023 - melaonin-research.com
Melatonin (MEL), an indoleamine hormone synthesized in almost all organisms including humans, has been the object of a considerable body of research due to its pleiotropic …
PH Scarpelli, G Tessarin‐Almeida… - Journal of Pineal …, 2019 - Wiley Online Library
Malaria causes millions of deaths worldwide and is considered a huge burden to underdeveloped countries. The number of cases with resistance to all antimalarials is …
The host hormone melatonin is known to modulate the asexual cell-cycle of the human malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental in the …
Plasmodium, a digenetic parasite, requires a host and a vector for its life cycle completion. Most Plasmodium species display circadian rhythmicity during their intraerythrocytic cycle …
The indoleamine compound melatonin has been extensively studied in the regulation of the circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in …
BKM Dias, M Nakabashi, MRR Alves… - Journal of Pineal …, 2020 - Wiley Online Library
Melatonin and its indoles derivatives are central in the synchronization of malaria parasites. In this research, we discovered that melatonin is unable to increase the parasitemia in the …