Malaria is an infectious disease and a serious public health problem in the world, with 3.3
billion people in endemic areas in 100 countries and about 200 million new cases each …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs
in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …

The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-
cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most …

Melatonin (MEL), an indoleamine hormone synthesized in almost all organisms including
humans, has been the object of a considerable body of research due to its pleiotropic …

Malaria causes millions of deaths worldwide and is considered a huge burden to
underdeveloped countries. The number of cases with resistance to all antimalarials is …

The host hormone melatonin is known to modulate the asexual cell-cycle of the human
malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental in the …

Plasmodium, a digenetic parasite, requires a host and a vector for its life cycle completion.
Most Plasmodium species display circadian rhythmicity during their intraerythrocytic cycle …

The indoleamine compound melatonin has been extensively studied in the regulation of the
circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in …

Melatonin and its indoles derivatives are central in the synchronization of malaria parasites.
In this research, we discovered that melatonin is unable to increase the parasitemia in the …