[HTML][HTML] Therapeutic outcomes of isatin and its derivatives against multiple diseases: Recent developments in drug discovery
Isatin (1 H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in
humans and different plants. The isatin nucleus and its derivatives are owed the attention of …
humans and different plants. The isatin nucleus and its derivatives are owed the attention of …
Isatin derivatives with potential antitubercular activities
D Jiang, GQ Wang, X Liu, Z Zhang… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi …
J Haribabu, V Garisetti, RE Malekshah… - Journal of molecular …, 2022 - Elsevier
Abstract Two heterocyclic azole compounds, 3-(2, 3-dihydrobenzo [d] thiazol-2-yl)-4H-
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
Synthesis, structural elucidation, DFT investigations, biological evaluation and molecular docking studies of tetraamide-based macrocyclic cobalt (II) complexes
A new series of 16–18 membered cobalt (II) macrocyclic complexes derived by 3, 4-
diaminobenzophenone have been synthesized. The elemental analysis, FT-IR, 1H NMR …
diaminobenzophenone have been synthesized. The elemental analysis, FT-IR, 1H NMR …
Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells
C Balachandran, J Haribabu, K Jeyalakshmi… - Journal of Inorganic …, 2018 - Elsevier
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …
derivatives have been synthesized and their structural and biological characteristics have …
Synthesis of Ni (II) complexes bearing indole-based thiosemicarbazone ligands for interaction with biomolecules and some biological applications
A series of new Ni (II) complexes containing indole-based thiosemicarbazone ligands was
synthesized and characterized by elemental analyses, and UV–visible, FT-IR, 1 H & 13 C …
synthesized and characterized by elemental analyses, and UV–visible, FT-IR, 1 H & 13 C …
Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding …
KNA Rahman, J Haribabu, C Balachandran… - Polyhedron, 2017 - Elsevier
A new 3-acetylcoumarin thiosemicarbazone (AcTsc) and its copper (II)(1), nickel (II)(2) and
zinc (II)(3) complexes were synthesized and characterized by elemental analysis, UV–Vis …
zinc (II)(3) complexes were synthesized and characterized by elemental analysis, UV–Vis …
[HTML][HTML] Synthesis, structural characterization, thermal analysis, DFT, biocidal evaluation and molecular docking studies of amide-based Co (II) complexes
Many distinct amino acid and aromatic amine-derived transition metal complexes are used
as physiologically active compounds. A few Cobalt (II) complexes have been synthesized by …
as physiologically active compounds. A few Cobalt (II) complexes have been synthesized by …
Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …
Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N (4) substituted thiosemicarbazone based copper (II)/nickel (II) …
M Muralisankar, J Haribabu, NSP Bhuvanesh… - Inorganica Chimica …, 2016 - Elsevier
Abstract N-ethyl-2-(phenyl (pyridin-2-yl) methylene) hydrazinecarbothioamide (HBpyeTsc)
was obtained from 4-ethyl-3-thiosemicarbazide and 2-benzoylpyridine. The complexes …
was obtained from 4-ethyl-3-thiosemicarbazide and 2-benzoylpyridine. The complexes …