T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects
the progression of the immune response including autoimmune diseases. Antigen …

Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from
dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR) …

Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected
and tumor cells. To understand the temporal relationships between key events leading to …

The mechanisms driving pathological beta‐amyloid (Aβ) generation in late‐onset
Alzheimer's disease (AD) are unclear. Two late‐onset AD risk factors, Bin1 and CD 2 AP, are …

Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable
specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell …

T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during
development to respond to changes in peptides displayed by major histocompatibility …

Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …

The molecular mechanisms that allow HIV to integrate into particular sites of the host
genome are poorly understood. Here we tested if the nuclear pore complex (NPC) facilitates …

T cell surfaces are covered with microvilli, actin-rich and flexible protrusions. We use super-
resolution microscopy to show that≥ 90% of T cell receptor (TCR) complex molecules …