Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2
diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be …

Being the largest and most accessible organ of the human body, the skin could offer a
window to diabetes-related complications on the microvasculature. However, skin …

Insulin resistance is frequently associated with endothelial dysfunction and has been
proposed to play a major role in cardiovascular diseases. Insulin exerts pro-and anti …

The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

The endothelium forms an important part of the vasculature and is involved in promoting an
atheroprotective environment via the complementary actions of endothelial cell-derived …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Cardiovascular disease is a major complication of diabetes mellitus, and improved
strategies for prevention and treatment are needed. Endothelial dysfunction contributes to …

Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular
disease. This can be partly explained by large-artery dysfunction, which already occurs in …