Equilibrium mechanisms of self-limiting assembly

MF Hagan, GM Grason - Reviews of modern physics, 2021 - APS
Self-assembly is a ubiquitous process in synthetic and biological systems, broadly defined
as the spontaneous organization of multiple subunits (macromolecules, particles, etc.) into …

The role of actin cytoskeleton in dendritic spines in the maintenance of long-term memory

S Basu, R Lamprecht - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Evidence indicates that long-term memory formation involves alterations in synaptic efficacy
produced by modifications in neural transmission and morphology. However, it is not clear …

The role of ADF/cofilin in synaptic physiology and Alzheimer's disease

Y Ben Zablah, N Merovitch, Z Jia - Frontiers in Cell and …, 2020 - frontiersin.org
Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium

M Bell, T Bartol, T Sejnowski… - Journal of General …, 2019 - rupress.org
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and
are important for signaling activity and synaptic communication. These subcompartments …

Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome

V Mercaldo, B Vidimova, D Gastaldo, E Fernández… - Neuron, 2023 - cell.com
The proteome of glutamatergic synapses is diverse across the mammalian brain and
involved in neurodevelopmental disorders (NDDs). Among those is fragile X syndrome …

Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model

A Androuin, B Potier, UV Nägerl, D Cattaert… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is associated with a progressive loss of synapses and neurons.
Studies in animal models indicate that morphological alterations of dendritic spines precede …

The role of Rac GTPase in dendritic spine morphogenesis and memory

JF Costa, M Dines, R Lamprecht - Frontiers in synaptic neuroscience, 2020 - frontiersin.org
The ability to form memories in the brain is needed for daily functions, and its impairment is
associated with human mental disorders. Evidence indicates that long-term memory (LTM) …

Mechanical principles governing the shapes of dendritic spines

H Alimohamadi, MK Bell, S Halpain… - Frontiers in …, 2021 - frontiersin.org
Dendritic spines are small, bulbous protrusions along the dendrites of neurons and are sites
of excitatory postsynaptic activity. The morphology of spines has been implicated in their …

Regulation of actin dynamics in dendritic spines: Nanostructure, molecular mobility, and signaling mechanisms

S Okabe - Molecular and Cellular Neuroscience, 2020 - Elsevier
Dendritic spines are major sites of excitatory synaptic connection in pyramidal neurons of
the forebrain, and their functional regulation underlies the development of functional …

MTSS1 regulation of actin-nucleating formin DAAM1 in dendritic filopodia determines final dendritic configuration of Purkinje cells

KK Galbraith, K Fujishima, H Mizuno, SJ Lee… - Cell reports, 2018 - cell.com
Dendritic filopodia of developing neurons function as environmental sensors, regulating the
spatial organization of dendrites and proper targeting to presynaptic partners. Dendritic …