Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The combination of immunotherapy and molecular targeted therapy exhibits promising
therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still …

Lysine succinylation is one of the major post-translational modifications occurring on
histones and is believed to have significant roles in regulating chromatin structure and …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

A number of studies have shown that aspirin, as commonly prescribed drug, prevents the
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …