The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …

Memories initially formed in hippocampus gradually stabilize to cortex over weeks-to-months
for long-term storage. The mechanistic details of this brain re-organization remain poorly …

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and
anxiety, but the specific factors that engage the BNST in defensive behaviors are unclear …

In humans and rodents, the entorhinal cortical (EC)‐hippocampal (HPC) circuit is crucial for
the formation and recall of memory, preserving both spatial information and temporal …

HIV-associated neurocognitive disorder (HAND) affects approximately half of HIV-infected
patients. Loss of synaptic connections is a hallmark of many neurocognitive disorders …

Fear memory is a highly stable and durable form of memory, even over vast (remote) time
frames. Nevertheless, some elements of fear memory can be forgotten, resulting in …

Anxiety disorders are the most prevalent mental illnesses worldwide, exhibit high heritability,
and affect twice as many women as men. To evaluate potential interactions between genetic …

The ketogenic diet is highly effective at attenuating seizures in refractory epilepsy, and
accumulating evidence in the literature suggests that it may be beneficial in autism. To our …

Treatment of Post-Traumatic Stress Disorder (PTSD) is complicated by the presence of drug
use disorder comorbidity. Here, we examine whether conditioned fear (PTSD model) …

In this review, we advocate a dimensional approach on the basis of candidate
endophenotypes to the development of animal models of post-traumatic stress disorder …