The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Background & Aims Cirrhosis results from accumulation of myofibroblasts derived from
quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC),
but also sinusoidal endothelial cells, dendritic cells (DC) and other immune cells are …

INTRODUCTION The Hedgehog (Hh) pathway is critical for embryogenesis and tissue
regeneration. Hh signaling is activated by binding of the secreted and lipid-modified protein …

Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan
development. Hh proteins have been shown to play roles in many developmental processes …