The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

Background: Antimicrobial resistance is a serious public-health problem throughout the
world. Escherichia coli, the most common Gram-negative microorganism, has developed …

The worldwide spread of carbapenem-and polymyxin-resistant Enterobacterales represents
an urgent public-health threat. However, for most countries in the Americas, the available …

In the last decade, polymyxins have been reintroduced in the therapeutic arsenal to treat
severe infections by carbapenem-resistant Enterobacterales. At that time, reports of …

Background Colistin is used as a last resort for managing infections caused by multidrug-
resistant bacteria. However, the high emergence of colistin-resistant strains has restricted …

ABSTRACT NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This
compound exhibits activity against Enterobacteriaceae pathogens, including …

The incidence of infections caused by resistant Gram-negative pathogens has become a
critical factor in public health due to the limitation of therapeutic options for the control of …

Antimicrobial resistance represents a global dilemma. Our present study aimed to
investigate the presence of mcr-1 among different Gram-negative bacteria including …

Polymyxins are still used mainly in treating infections caused by carbapenem-resistant
Klebsiella pneumoniae worldwide. The most frequent mechanism of acquired resistance to …