[HTML][HTML] The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

[HTML][HTML] SARS-CoV-2 viral load and shedding kinetics

O Puhach, B Meyer, I Eckerle - Nature Reviews Microbiology, 2023 - nature.com
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two
key parameters for estimating infectiousness. As shedding of infectious virus is required for …

[HTML][HTML] Prevalence of persistent SARS-CoV-2 in a large community surveillance study

M Ghafari, M Hall, T Golubchik, D Ayoubkhani, T House… - Nature, 2024 - nature.com
Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

[HTML][HTML] Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study

CKH Wong, KTK Lau, ICH Au, EHY Lau… - The Lancet infectious …, 2023 - thelancet.com
Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the
clinical management and isolation of patients with COVID-19. We evaluated an unselected …

Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection

S Miyamoto, T Nishiyama, A Ueno… - Proceedings of the …, 2023 - National Acad Sciences
Infectious virus shedding from individuals infected with severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2) is used to estimate human-to-human transmission risk. Control …

[HTML][HTML] SARS-CoV-2 rebound with and without use of COVID-19 oral antivirals

DJ Smith - MMWR. Morbidity and Mortality Weekly Report, 2023 - cdc.gov
Early treatment with a first-line therapy (nirmatrelvir/ritonavir [Paxlovid] or remdesivir) or
second-line therapy (molnupiravir) prevents hospitalization and death among patients with …

[HTML][HTML] SARS-CoV-2 Omicron variant, lineage BA. 1, is associated with lower viral load in nasopharyngeal samples compared to Delta variant

C Sentis, G Billaud, A Bal, E Frobert, M Bouscambert… - Viruses, 2022 - mdpi.com
Objectives: High viral load in upper respiratory tract specimens observed for Delta cases
might contribute to its increased infectivity compared to the other variant. However, it is not …

Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2

SW Park, K Sun, S Abbott, R Sender… - Proceedings of the …, 2023 - National Acad Sciences
Estimating the differences in the incubation-period, serial-interval, and generation-interval
distributions of SARS-CoV-2 variants is critical to understanding their transmission …

[HTML][HTML] Biological properties of SARS-CoV-2 variants: epidemiological impact and clinical consequences

R Hoteit, HM Yassine - Vaccines, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to
the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May …

[HTML][HTML] Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses

K Owens, S Esmaeili, JT Schiffer - JCI insight, 2024 - ncbi.nlm.nih.gov
The viral kinetics of documented SARS-CoV-2 infections exhibit a high degree of
interindividual variability. We identified 6 distinct viral shedding patterns, which differed …