Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes,
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-
regulatory elements that control patterns of gene expression in multicellular organisms …

To determine how different pioneer transcription factors form a targeted, accessible
nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …

How different intrinsic sequence variations and regulatory modifications of histones combine
in nucleosomes remain unclear. To test the importance of histone variants in the …

Mobile transposable elements (TEs) not only participate in genome evolution but also
threaten genome integrity. In healthy cells, TEs that encode all of the components that are …

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated
by kinetochores, which are unique chromosomal sites for microtubule attachment …

Little is known about how combinations of histone marks are interpreted at the level of
nucleosomes. The second PHD finger of human BPTF is known to specifically recognize …

The vasculature is an essential organ for the delivery of blood and oxygen to all tissues of
the body and is thus relevant to the treatment of ischaemic diseases, injury-induced …

The assembly of mitotic chromosomes, each composed of a pair of rod-shaped chromatids,
is an essential prerequisite for accurate transmission of the genome during cell division. It …