The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …

Drug-induced cardiotoxicity arises primarily when a compound alters the
electrophysiological properties of cardiomyocytes. Features of intracellular action potentials …

Human heart failure due to myocardial infarction is a major health concern. The paucity of
organs for transplantation limits curative approaches for the diseased and failing adult heart …

Improved methodologies for modeling cardiac disease phenotypes and accurately
screening the efficacy and toxicity of potential therapeutic compounds are actively being …

Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological
changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal …