Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

[HTML][HTML] Biotechnological applications of bacteriophages: State of the art

LK Harada, EC Silva, WF Campos, FS Del Fiol… - Microbiological …, 2018 - Elsevier
Bacteriophage particles are the most abundant biological entities on our planet, infecting
specific bacterial hosts in every known environment and being major drivers of bacterial …

[HTML][HTML] Engineering phage host-range and suppressing bacterial resistance through phage tail fiber mutagenesis

K Yehl, S Lemire, AC Yang, H Ando, M Mimee… - Cell, 2019 - cell.com
The rapid emergence of antibiotic-resistant infections is prompting increased interest in
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …

More is better: selecting for broad host range bacteriophages

A Ross, S Ward, P Hyman - Frontiers in microbiology, 2016 - frontiersin.org
Bacteriophages are viruses that infect bacteria. In this perspective, we discuss several
aspects of a characteristic feature of bacteriophages, their host range. Each phage has its …

Microbiome and gut dysbiosis

JE Belizário, J Faintuch - Metabolic interaction in infection, 2018 - Springer
The gastrointestinal (GI) tract is the residence of trillions of microorganisms that include
bacteria, archaea, fungi and viruses. The collective genomes of whole microbial …

Biodiversity of bacteriophages: morphological and biological properties of a large group of phages isolated from urban sewage

A Jurczak-Kurek, T Gąsior, B Nejman-Faleńczyk… - Scientific reports, 2016 - nature.com
A large scale analysis presented in this article focuses on biological and physiological
variety of bacteriophages. A collection of 83 bacteriophages, isolated from urban sewage …

Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies

K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …

Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo

JY Nale, J Spencer, KR Hargreaves… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The microbiome dysbiosis caused by antibiotic treatment has been associated with both
susceptibility to and relapse of Clostridium difficile infection (CDI). Bacteriophage (phage) …

Application of bacteriophages in the agro-food sector: A long way toward approval

L Fernández, D Gutiérrez, A Rodríguez… - Frontiers in cellular and …, 2018 - frontiersin.org
The rapid increase in multi-drug resistant (MDR) pathogens has put notable pressure on
Health Authorities, who foresee an uncertain future for global human health. In June 2017 …

Novel approaches to the treatment of bacterial biofilm infections

G Hughes, MA Webber - British journal of pharmacology, 2017 - Wiley Online Library
Bacterial infection remains a major challenge to healthcare and is responsible for significant
morbidity and mortality. This situation is becoming complicated by an increasingly ageing …