Objectives The treatment of inner ear disorders remains challenging due to anatomic
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …

Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …

Background Inner ear diagnostics is limited by the inability to atraumatically obtain samples
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …

Drug delivery into the inner ear is a significant challenge due to its inaccessibility as a fluid-
filled cavity within the temporal bone of the skull. The round window membrane (RWM) is the …

Bioanalyte collection by blood draw is a painful process, prone to needle phobia and
injuries. Microneedles can be engineered to penetrate the epidermal skin barrier and collect …

Background: An intact round window membrane is a barrier to delivery of therapeutic and
diagnostic agents into the inner ear. Microperforation of the guinea pig round window …

Background: Reliable delivery of agents into the inner ear for therapeutic and diagnostic
purposes remains a challenge. Our novel approach employs microneedles to facilitate …

N-acetylcysteine is a thiol-containing antioxidant, which has shown otoprotective effects in in
vitro as well as in vivo models of cisplatin-induced hearing loss. Systemic administration of …

Glucocorticoids are the first-line treatment for sensorineural hearing loss, but little is known
about the mechanism of their protective effect or the impact of route of administration. The …

Objectives: Precision medicine for inner ear disorders has seen significant advances in
recent years. However, unreliable access to the inner ear has impeded diagnostics and …