Allostery and the Monod-Wyman-Changeux model after 50 years
JP Changeux - Annual review of biophysics, 2012 - annualreviews.org
The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …
signal transduction and cooperative properties of bacterial regulatory enzymes and …
Mechanisms of action and persistent neuroplasticity by drugs of abuse
ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …
important for the homeostasis of brain processes and for learning and remembering …
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
Abstract γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
PJ Corringer, F Poitevin, MS Prevost, L Sauguet… - Structure, 2012 - cell.com
Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …
central and peripheral nervous systems have been found in several bacterial species and in …
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Molecular simulation approaches to membrane proteins
PJ Stansfeld, MSP Sansom - Structure, 2011 - cell.com
Molecular simulations are an invaluable tool for understanding membrane proteins.
Improvements to both hardware and simulation methods have allowed access to …
Improvements to both hardware and simulation methods have allowed access to …
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel
Ethanol alters nerve signalling by interacting with proteins in the central nervous system,
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis …
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis …
[PDF][PDF] Toxicology and the biological role of methanol and ethanol: Current view.
M Pohanka - Biomedical Papers of the Medical Faculty of …, 2016 - biomed.papers.upol.cz
Background. Alcohol variants such as ethanol and methanol are simple organic compounds
widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an …
widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an …
Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs
Nociception and motor coordination are critically governed by glycine receptor (GlyR)
function at inhibitory synapses. Consequentially, GlyRs are attractive targets in the …
function at inhibitory synapses. Consequentially, GlyRs are attractive targets in the …