Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Advancing age is associated with several age-related diseases (ARDs), with
musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic …

Endothelial defects significantly contribute to cardiovascular pathology in the premature
aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium …

Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the
physiopathology of atherosclerosis are cellular senescence, oxidative stress, and …

Senescence is a complex cellular process that is implicated in various physiological and
pathological processes. It is characterized by a stable state of cell growth arrest and by a …

Severe pneumonia may induce sequelae and accelerated aging process even after the
person has recovered. However, the underline mechanism is not very clear. More research …

This investigation addressed the impact of integrin-initiated signaling pathways on
senescence of tumor cells. In a model of human SK-Mel-147 melanoma cells, the silencing …

Cellular senescence is a permanent cell cycle arrest that can be triggered by both internal
and external genotoxic stressors, such as telomere dysfunction and DNA damage. The …

For the past 70 years, the dopamine hypothesis has been the key working model in
schizophrenia. This has contributed to the development of numerous inhibitors of …

Cathepsin L (CTSL) has been implicated in aging and age-related diseases, such as
cardiovascular diseases, specifically atherosclerosis. However, the underlying mechanism …