The expanding scope of antimicrobial peptide structures and their modes of action

LT Nguyen, EF Haney, HJ Vogel - Trends in biotechnology, 2011 - cell.com
Antimicrobial peptides (AMPs) are an integral part of the innate immune system that protect
a host from invading pathogenic bacteria. To help overcome the problem of antimicrobial …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

DKV Kumar, SH Choi, KJ Washicosky… - Science translational …, 2016 - science.org
The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Exploring pathological link between antimicrobial and amyloid peptides

Y Tang, Y Zhang, D Zhang, Y Liu, R Nussinov… - Chemical Society …, 2024 - pubs.rsc.org
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …

Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease

R Lathe, D St. Clair - Biological Reviews, 2023 - Wiley Online Library
The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Antimicrobial peptides and copper (II) ions: Novel therapeutic opportunities

J Portelinha, SS Duay, SI Yu, K Heilemann… - Chemical …, 2021 - ACS Publications
The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

A mechanistic survey of Alzheimer's disease

Y Tang, D Zhang, X Gong, J Zheng - Biophysical chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Prion protein at the crossroads of physiology and disease

E Biasini, JA Turnbaugh, U Unterberger… - Trends in neurosciences, 2012 - cell.com
The presence of the cellular prion protein (PrP C) on the cell surface is critical for the
neurotoxicity of prions. Although several biological activities have been attributed to PrP C, a …

Functionalization of biomolecules on nanoparticles: specialized for antibacterial applications

M Veerapandian, K Yun - Applied microbiology and biotechnology, 2011 - Springer
Biological efficiency of existing antimicrobial agents is still inadequate to ensure optimal
therapeutic index. Developing biocompatible advanced functional materials with …