In order to proliferate in unfavourable conditions, cancer cells can take advantage of the
naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via …

Background Cancer is still an all-times issue due to a large and even increasing number of
deaths. Impaired genes regulating cell proliferation and apoptosis are targets for the …

Global changes in chromatin accessibility may drive cancer progression by reprogramming
transcription factor (TF) binding. In addition, histone acetylation readers such as …

Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer
death among men worldwide. While the five-year survival in local and regional prostate …

Steroid hormone signaling is critical in the tumor progression and the regulation of
physiological mechanisms such as endoplasmic reticulum-associated degradation (ERAD) …

A need exists for seeking effective treatments for castration-resistant prostate cancer (CRPC)
in response to its emergence following androgen deprivation therapy as a major clinical …

Dysregulation of autophagy has been implicated in the development of many diseases,
including cancer. Here, we revealed a novel function of the E3 ubiquitin ligase HRD1 in non …

Prostate cancer (PCa) is the second most common type of cancer and the sixth cause of
death in men worldwide. Radiotherapy and immunotherapy are commonly used in treating …

We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in
breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell …

Background Castration‐resistant prostate cancer (PCa) represents a serious health
challenge. Based on mechanistically‐supported rationale we explored new therapeutic …