The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …

Fasciolosis, a food‐borne trematodiasis, results following infection with the parasites,
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …

Flatworms number among the most diverse invertebrate phyla and represent the most
biomedically significant branch of the major bilaterian clade Spiralia, but to date, deep …

As a key event for maintaining life cycles, reproduction is a central part of platyhelminth
biology. In case of parasitic platyhelminths, reproductive processes can also contribute to …

CRISPR/Cas9-based genome editing has yet to be reported in species of the
Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma …

Planarians have emerged as excellent models for the study of key biological processes such
as stem cell function and regulation, axial polarity specification, regeneration, and tissue …

The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following
ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge …

The last half-century has provided all of the (few) drugs currently used to treat human
helminthiases. Concern regarding the long-term utility of these drugs, given how readily …

Background It is believed that in tapeworms a separate population of undifferentiated cells,
the germinative cells, is the only source of cell proliferation throughout the life cycle (similar …

Schistosomes are parasitic flatworms causing one of the most prevalent infectious diseases
from which millions of people are currently suffering. These parasites have high fecundity …