Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …

KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS
aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to …

The significance of fatty acid metabolism in cancer initiation and development is increasingly
accepted by scientists and the public due to the high prevalence of overweight and obese …

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological
end point of cancer. We review here numerous affected oncogenes and metabolic pathways …

The malignant transformation of cells requires adaptations across multiple metabolic
processes to satisfy the energy required for their increased rate of proliferation …

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis
plays an important role in tumour cell survival. These observations suggest that enzymes in …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …