Recent advances in anti-tuberculosis drug discovery based on hydrazide–hydrazone and thiadiazole derivatives targeting inhA

Y Teneva, R Simeonova, V Valcheva, VT Angelova - Pharmaceuticals, 2023 - mdpi.com
Tuberculosis is an extremely serious problem of global public health. Its incidence is
worsened by the presence of multidrug-resistant (MDR) strains of Mycobacterium …

Design, synthesis, and anticancer evaluation of novel tetracaine hydrazide-hydrazones

Mİ Han, N Imamoglu - ACS omega, 2023 - ACS Publications
Tetracaine is an ester derivative used as a local anesthetic molecule. In this study, a series
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …

Synthesis of isoniazid analogs with promising antituberculosis activity and bioavailability: biological evaluation and computational studies

R Gavadia, J Rasgania, MV Basil, V Chauhan… - Journal of Molecular …, 2023 - Elsevier
A series of aliphatic isoniazid carbo (x/thio) amides has been synthesized by a facile one-pot
green method in aqueous media by harnessing microwave irradiations. In vitro …

Isoniazid Hybrids As Potential Antitubercular Agents

S Mishra, G Kumar, P Singh - ChemistrySelect, 2024 - Wiley Online Library
The rapid emergence of various forms of drug‐resistant tuberculosis (TB) has massively
impacted people's health globally. According to the WHO, TB care and facilities have been …

Novel isoniazid-hydrazone derivatives induce cell growth inhibition, cell cycle arrest and apoptosis via mitochondria-dependent caspase activation and PI3K/AKT …

K Rouzi, A Altay, M Bouatia, E Yeniçeri, MS Islam… - Bioorganic …, 2024 - Elsevier
In this study, seven isoniazid-hydrazone derivatives (3a-g) were synthesized and their
structures elucidated by chromatographic techniques, and then the antiproliferative effects of …

Evaluation of the cytotoxic and antimicrobial potential of epiphytic biomass obtained from Laminaria hyperborea biorefinery side-streams

A Barouti, L Herfindal, SK Vagolu… - Frontiers in Marine …, 2024 - frontiersin.org
Harvested Laminaria hyperborea contributes to approximately 3.3 million tonnes of
epiphytes discarded as waste despite containing organisms such as red algae and bryozoa …

Hydrazone‐Tethered 5‐(Pyridin‐4‐yl)‐4H‐1,2,4‐triazole‐3‐thiol Hybrids: Synthesis, Characterisation, in silico ADME Studies, and in vitro Antimycobacterial …

OO Oderinlo, A Jordaan, R Seldon, M Isaacs… - …, 2023 - Wiley Online Library
Abstract Compounds containing arylpyrrole‐, 1, 2, 4‐triazole‐and hydrazone structural
frameworks have been widely studied and demonstrated to exhibit a wide range of …

Na2S2O3 Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

Y Bi, J Wang, X Bian, M Chen, G Zhu… - Chemistry & …, 2024 - Wiley Online Library
An efficient and green method for synthesizing 3‐methyl‐4‐(hetero) arylmethylene isoxazole‐
5 (4H)‐ones was developed using a recyclable and environmental–friendly catalyst …

Structure-based drug design and characterization of novel pyrazine hydrazinylidene derivatives with a benzenesulfonate scaffold as noncovalent inhibitors of DprE1 …

Shivakumar, P Dinesha, D Udayakumar - Molecular Diversity, 2024 - Springer
In this study, we present a novel series of (E)-4-((2-(pyrazine-2-carbonyl) hydrazineylidene)
methyl) phenyl benzenesulfonate (T1-T8) and 4-((E)-(((Z)-amino (pyrazin-2-yl) methylene) …

Cinnamate-amine hybrids: Antituberculosis activity and molecular docking

NP Aijijiyah, R Rahayu, A Srilistiani… - Journal of Applied …, 2024 - japsonline.com
Antituberculosis activity and molecular docking experiments were performed on 14
cinnamate-amine hybrids. Cinnamamides 1a, b, c, d, i, j effectively inhibited the growth of …