Protein phosphorylation and neuronal function.

SI Walaas, P Greengard - Pharmacological Reviews, 1991 - pharmrev.aspetjournals.org
Following the initial demonstration of phosphorylation of endogenous brain proteins
(Johnson et al., 1971), two decades of work have shown that this biochemical mechanism …

Neurofilament phosphorylation: a new look at regulation and function

RA Nixon, RK Sihag - Trends in neurosciences, 1991 - cell.com
Dynamic remodeling of cytoskeleton architecture is necessary for axonal growth and
guidance, signal transduction and other fundamental aspects of neuron function. Protein …

Effects of short‐and long‐term Schwann cell denervation on peripheral nerve regeneration, myelination, and size

OAR Sulaiman, T Gordon - Glia, 2000 - Wiley Online Library
Poor functional recovery after peripheral nerve injury has been generally attributed to
inability of denervated muscles to accept reinnervation and recover from denervation …

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

F Côté, JF Collard, JP Julien - Cell, 1993 - cell.com
We generated four transgenic mice with a 34 kb genomic fragment including the complete
human neurofiiament heavy (NF-H) gene. This human NF-H fragment contained ail …

Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns

MJ Carden, JQ Trojanowski… - Journal of …, 1987 - Soc Neuroscience
Monoclonal antibodies (mAbs) to rat neurofilament (NF) proteins NF-L, NF-M, and NF-H
were used to examine the developmental programs of NF expression in rat embryos. The …

Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury

G Shaw, C Yang, R Ellis, K Anderson, JP Mickle… - Biochemical and …, 2005 - Elsevier
Several lines of reasoning suggest that the phosphorylated axonal form of the neurofilament
subunit NF-H is likely to be released from damaged and diseased neurons in significant …

Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-β-galactosidase fusion protein

J Eyer, A Peterson - Neuron, 1994 - cell.com
Interactions between neurofilament side arms may modulate axon caliber. To investigate
this hypothesis, we derived transgenic mice expressing a fusion protein in which the …

Molecular cloning and primary structure of human glial fibrillary acidic protein.

SA Reeves, LJ Helman, A Allison… - Proceedings of the …, 1989 - National Acad Sciences
Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly
specific for cells of astroglial lineage, although its tissue-specific role is speculative …

Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation

I Sánchez, L Hassinger, PA Paskevich… - Journal of …, 1996 - Soc Neuroscience
Axon caliber may be influenced by intrinsic neuronal factors and extrinsic factors related to
myelination. To understand these extrinsic influences, we studied how axon-caliber …

Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation …

RA Nixon, PA Paskevich, RK Sihag… - The Journal of cell …, 1994 - rupress.org
The high molecular weight subunits of neurofilaments, NF-H and NF-M, have distinctively
long carboxyl-terminal domains that become highly phosphorylated after newly formed …