Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Sepsis, defined as an infection with dysregulated host response leading to life‐threatening
organ dysfunction, continues to carry a high potential for morbidity and mortality in children …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Rationale: Limited data exist about the international burden of severe sepsis in critically ill
children. Objectives: To characterize the global prevalence, therapies, and outcomes of …

Importance The death of a pediatric patient with sepsis motivated New York to mandate
statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Objectives: Delayed antimicrobials are associated with poor outcomes in adult sepsis, but
data relating antimicrobial timing to mortality and organ dysfunction in pediatric sepsis are …

Objective: To 1) describe the characteristics and outcomes over time of PICU patients with
severe sepsis within the dedicated US children's hospitals, 2) identify patient subgroups at …

Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …

Objectives: To compare the prevalence, resource utilization, and mortality for pediatric
severe sepsis identified using two established identification strategies. Design …