There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Protein phosphorylation plays a cardinal role in regulating many cellular processes in
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …

The transcription factor CREB? for'cyclic AMP response element-binding protein'? functions
in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in …

▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …

CREB is a transcription factor implicated in the control of adaptive neuronal responses.
Although one function of CREB in neurons is believed to be the regulation of genes whose …

The transcription factor CREB is best known for its involvement in learning and memory.
However, emerging evidence suggests that CREB activity has very different roles …

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that
are activated by dual phosphorylation on threonine and tyrosine residues in response to a …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To
understand how neurotrophins elicit such diverse responses, we elucidated signaling …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

The nuclear factor CREB stimulates the expression of cellular genes following its protein
kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates …