[HTML][HTML] Promises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
[HTML][HTML] The origin of ovarian cancer species and precancerous landscape
Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment
Transcriptional heterogeneity among malignant cells of a tumor has been studied in
individual cancer types and shown to be organized into cancer cell states; however, it …
individual cancer types and shown to be organized into cancer cell states; however, it …
Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer
Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
A single-cell landscape of high-grade serous ovarian cancer
Malignant abdominal fluid (ascites) frequently develops in women with advanced high-
grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …
grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …
Heterogeneity and treatment landscape of ovarian carcinoma
AC Veneziani, E Gonzalez-Ochoa, H Alqaisi… - Nature Reviews …, 2023 - nature.com
Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …
anatomical levels, both spatially and temporally. This heterogeneity affects response to …
[HTML][HTML] The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to SARS-CoV-2 infection
J Qi, Y Zhou, J Hua, L Zhang, J Bian, B Liu… - International Journal of …, 2021 - mdpi.com
COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs,
suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the …
suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the …
[HTML][HTML] Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and
immunological characteristics that remain unclear. Here, we perform transcriptomic analysis …
immunological characteristics that remain unclear. Here, we perform transcriptomic analysis …
[HTML][HTML] Biology-driven therapy advances in high-grade serous ovarian cancer
Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …
[HTML][HTML] Integration of scRNA-Seq and bulk RNA-Seq to analyse the heterogeneity of ovarian cancer immune cells and establish a molecular risk model
L Liang, J Yu, J Li, N Li, J Liu, L Xiu, J Zeng… - Frontiers in …, 2021 - frontiersin.org
Background Considerable evidence suggests that the heterogeneity of ovarian cancer (OC)
is a major cause of treatment failure. Single-cell RNA sequencing (scRNA-seq) is a powerful …
is a major cause of treatment failure. Single-cell RNA sequencing (scRNA-seq) is a powerful …