The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-
cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a …

Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …

Aims Multiple myeloma (MM) is the second hematological plasma cell malignany and
sensitive to fingolimod (FTY720), a novel immunosuppressant. Previous study shows …

Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate
(S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell …

Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …

For decades, sphingolipids have been related to several biological functions such as
immune system regulation, cell survival, and proliferation. Recently, it has been reported that …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …

Ischemic stroke leads to neuronal damage induced by excitotoxicity, inflammation, and
oxidative stress. Astrocytes play diverse roles in stroke and ischemia‐induced inflammation …

As part of our ongoing search for novel therapeutic structures from microorganism, the
chemical examination of marine fungus Phoma sp. resulted in the isolation of ergosterol …