Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

Transcriptional activation of a gene involves an orchestrated recruitment of components of
the basal transcription machinery and intermediate factors, concomitant with an alteration in …

Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

▪ Abstract Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors
that function as intracellular sensors for sterols and bile acids, respectively. In response to …

Vitamin D 3 is produced non-enzymatically when the cholesterol precursor 7-
dehydrocholesterol is exposed to UV-B, ie, evolutionary the first function of the molecule was …

It took several hundred million years of evolution, in order to develop the endocrine vitamin
D signaling system, which is formed by a nuclear receptor, the transcription factor VDR …