Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

Zinc is required for the activity of> 300 enzymes, covering all six classes of enzymes. Zinc
binding sites in proteins are often distorted tetrahedral or trigonal bipyramidal geometry …

Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

Protein prenylation is a ubiquitous covalent post-translational modification found in all
eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It …

In this review, we summarize recent progress in studying three main classes of
prenyltransferases:(a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain …

The number of zinc enzymes for which detailed structural and mechanistic data, including
high resolution crystal structures, are available is increasing rapidly. The new finding …

Abstract R115777 {(B)-6-[amino (4-chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-
chlorophenyl)-1-methyl-2 (1H)-quinolinone} is a potent and selective inhibitor of farnesyl …

Some proteins undergo posttranslational modification by the addition of an isoprenyl lipid
(farnesyl-or geranylgeranyl-isoprenoid) to a cysteine residue proximal to the C terminus …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with
different aetiology, but both result in joint damage. The nutritionally essential metal zinc …